Protect Your Brain From Memory Loss Before Symptoms Appear, by Protecting Your Cells and Mitochondria with a Research-driven Combination of Natural Annatto Tocotrienol Vitamin E & Geranylgeraniol (GG)

Long before diagnosis, silent cellular damage contributes to the development of dementia, heart disease, cancer, type 2 diabetes and immune decline.

Oxidative stress and chronic inflammation disrupt mitochondrial function and cellular signalling, processes that are strongly linked to ageing-related disease.

Two rare, annatto-sourced compounds, tocotrienols and geranylgeraniol (GG), are among the most extensively researched natural nutrients shown to support cellular and mitochondrial resilience.

Unlike standard vitamin E products, this formulation combines annatto-derived tocotrienols with geranylgeraniol (GG) a rare pairing designed to support both mitochondrial protection and cellular signalling.

“The smallest unit of life is the cell. So, if your cells are healthy, you are healthy.”

- Mike Murphy, Professor of Mitochondrial Redox Biology & MitoQ co-creator

Leading mitochondrial researchers agree - disease begins at the cellular level.

REAL RESULTS FROM REAL AUSTRALIANS

TESTIMONIAL 1:
" I have been using Annatto Tocotrienol 300 mg for a month now and have been very impressed with its effectiveness. I have noticed an improvement in my overall level of physical vitality and clarity of mind. It has improved symptoms such as fatigue, chronic pain, general mood and has had a positive impact on my health diagnosis. It is an interesting supplement which I will continue taking to explore its benefits."
- Cas, Adelaide, SA

TESTIMONIAL 2:
"Before I started, my PSA levels had been rising for ten years. Over the last 18 months, they've fallen lower than two years ago. My doctor was genuinely surprised. The tocotrienol is the only supplement I use."
- Howard, 60+, NSW

TESTIMONIAL 3:
"More than happy to recommend this product and the great team at Natural Health Connect. I'm sleeping better, feeling more energetic, and my brain fog is gone."
- Robyn, 50+ NSW

TESTIMONIAL 4:
"I have lesions on the prostate and adrenal glands - both under control. Annatto DeltaGold tocotrienol and GG-Gold are in my view, lifesavers."
- Alex, 75+, Qld

"The smallest unit of life is the cell. If your cells are healthy, you are healthy."

– Prof. Mike Murphy, Mitochondrial Redox Biology, Cambridge

What Our Manufacturing Partner Says About Our Collaboration

" Partnering with Natural Health Connect has significantly expanded our reach and impact. Their commitment to a science-based approach aligns seamlessly with our mission to provide trustworthy, evidence-backed health solutions. This collaboration has allowed us to engage more meaningfully with our audience and deliver greater value to the communities we serve."

- Wellness Extract, Canadian Supplier & Manufacturer | 4.85/5.00 Satisfaction Rating | 100,000+ Customers Served

Research by Health Priority

Most chronic diseases do not begin suddenly, they develop silently over years of cumulative cellular damage. Explore how annatto tocotrienols and geranylgeraniol (GG) are studied in relation to the conditions that matter most as we age.

→ Dementia & Cognitive Health
→ Cardiovascular Health
→ Cancer Prevention & Support
→ Type 2 Diabetes & Metabolic Health
→ Healthy Ageing & Immune Function

Why Prevention Must Start at the Cellular Level

Most chronic diseases share common early drivers:

• Oxidative damage to lipids, proteins and DNA

• Mitochondrial dysfunction and impaired energy production

• Chronic, low-grade inflammation

• Disrupted cellular signalling and repair mechanisms

These processes begin years, often decades, before symptoms appear.

Annatto-sourced tocotrienols and geranylgeraniol (GG) are studied not as drugs, but as biological support compounds that help protect cellular integrity and resilience over time.

Why Annatto Matters

Not all vitamin E is the same.

• Tocotrienols from annatto are structurally and biologically distinct from common tocopherols

• Annatto provides delta- and gamma-tocotrienols only, the forms most studied for cellular protection

• Geranylgeraniol (GG) is a critical but declining compound involved in mitochondrial function and protein signalling

This is why research uses annatto and why we do too.

Image courtesy of Victoria Unversity

Backed by Victoria University’s analysis of 300+ studies, TGA‑listed DeltaGold™ tocotrienol (ARTG 373033) and FDA‑recognised GG‑Gold™, offer natural support for long‑term health.

Unlike standard antioxidants, annatto tocotrienols have demonstrated benefits across multiple organs, reflecting their fundamental role in cellular and mitochondrial protection, as can be seen below.

Seven Diseases They Address

Most doctors treat symptoms, not the root cause. Your cardiologist prescribes statins for cholesterol. Your endocrinologist prescribes metformin for blood sugar. Your oncologist prescribes chemotherapy for cancer. But they are all treating downstream consequences of the same three cellular mechanisms:

• Oxidative stress

• Chronic inflammation

• Insulin resistance (metabolic dysfunction

This triad is the silent driver behind heart disease, diabetes, dementia, cancer, fatty liver, osteoporosis and accelerated ageing. Conventional medications may lower one biomarker (cholesterol, glucose), but they rarely address the interconnected cycle of oxidative stress, inflammation and metabolic dysfunction that keeps disease progressing.​

Some medications can even aggravate parts of this triad:

• Statins reduce cholesterol by blocking HMG‑CoA reductase in the mevalonate pathway, which also decreases synthesis of CoQ10 and geranylgeranyl intermediates that support mitochondrial energy production and metabolic signalling. This depletion has been associated with muscle symptoms and may contribute to worsened mitochondrial function and insulin sensitivity in some patients.​

• Common diabetes drugs can lower blood glucose effectively, yet many do not directly suppress the chronic inflammatory and inflammasome pathways (for example, NLRP3) that sustain insulin resistance and tissue damage.​

• Chemotherapy is designed to kill rapidly dividing cells but also generates significant oxidative stress and inflammatory signalling in normal tissues, which can further damage mitochondria and DNA if not balanced by adequate antioxidant and anti‑inflammatory defences.​

There is a better approach: address all three pillars of the root‑cause cycle simultaneously – oxidative stress, chronic inflammation and insulin resistance (metabolic dysfunction) – at the cellular level.

The Solution - Two Compounds That Work Together

Why Prevention Fails (And What Actually Works)

Wellness Extract’s proprietary duo – EAnnatto 150+ vitamin E tocotrienols (DeltaGold®) with geranylgeraniol (GG‑Gold®) – is designed to act on the full root‑cause triad by addressing three interlinked cellular pathways:​

• Oxidative stress: Reactive oxygen species that damage DNA, proteins, lipids and mitochondria, accelerating cellular ageing and vulnerability to chronic disease. Tocotrienols have demonstrated potent antioxidant activity in experimental models, including protection of membranes and mitochondrial function.​

• Chronic inflammation: Persistent activation of NF‑κB and downstream pro‑inflammatory cytokines such as IL‑6, TNF‑α and IL‑1 that drive metabolic disease, cancer progression and neuroinflammation. Tocotrienols have been shown to downregulate NF‑κB signalling and reduce multiple inflammatory mediators in preclinical studies.​

• Metabolic dysfunction (insulin resistance): Impaired insulin signalling and altered energy metabolism, involving pathways such as AMPK and PI3K/Akt, that contribute to obesity, type 2 diabetes, fatty liver and cancer‑related growth signalling. Tocotrienols have been reported to modulate NLRP3 inflammasome activity, improve lipid handling in macrophages, and support glucose and lipid metabolism in animal models of metabolic syndrome and diabetes.​

These two compounds can act synergistically at multiple nodes in this network – oxidative stress, chronic inflammation and metabolic dysfunction – in a way that is fundamentally different from single‑target drugs that typically act on one pathway or biomarker at a time.

TOCOTRIENOL (DeltaGold™) - The Protector

Annatto Tocotrienol - Oxidative Stress + Inflammation Blocker

Annatto tocotrienol (particularly delta- and gamma-isoforms) is 40-60× more potent than standard vitamin E at neutralising free radicals (ROS) while crossing the blood-brain barrier, a rare trait for any nutrient. But its true power lies in pathway suppression:

• Inhibits NF-κB and PI3K/Akt: The same inflammatory and growth signalling pathways activated by hyperinsulinemia and driving cancer cell proliferation

• Restores IRS-1 insulin signaling: Helps reverse insulin resistance at the cellular level by protecting signalling proteins from oxidative damage

• Reduces pro-inflammatory cytokines: Clinical trials show 10-20% reductions in IL-6, TNF-α, and hs-CRP (systemic inflammation markers)

• PPARγ/α/δ activation: Enhances insulin sensitivity, reduces adipose inflammation, supports metabolic repair

Clinical validation: Victoria University meta-analysis (300+ studies, 2022); Pakistan RCTs showing HbA1c reduction and NAFLD improvement; Phase II breast cancer trial (2023) demonstrating chemotherapy synergy.

Result: Addresses oxidative stress AND inflammation pillars of the triad, with direct impacts on insulin resistance, metabolic disease, and cancer prevention.

GERANYLGERANIOL (GG‑Gold™) – The Restorer

Annatto geranylgeraniol (GG) – insulin sensitivity + energy support

GG is a mevalonate‑pathway intermediate that the body converts to geranylgeranyl pyrophosphate (GGPP), which participates in two critical processes:​

• Endogenous CoQ10 support: GG provides substrate for GGPP, which is required for the synthesis of the CoQ10 side chain, enabling mitochondria to maintain their own CoQ10 levels for electron transport and ATP production, particularly when the mevalonate pathway is partially blocked by statins.​

• Protein prenylation & signalling: GGPP geranylgeranylates small GTPases (Ras, Rho, Rac and others) that are essential for membrane localisation and signalling in pathways governing metabolism, insulin action and cell survival.​

• PPARγ modulation: Experimental work shows geranylgeraniol increases PPARγ expression and enhances PPARγ‑driven adipocyte biology, a mechanism linked with improved insulin sensitivity in adipose tissue. This also influences adipokines such as leptin and MCP‑1 that connect fat tissue to systemic inflammation.​

• Gut microbiome effects: In obese mouse models, dietary geranylgeraniol improved glucose homeostasis, reduced pro‑inflammatory adipokines and altered the gut microbiome, including increases in beneficial butyrate‑producing bacteria and reductions in taxa associated with obesity‑related metabolic dysfunction, helping to address metabolic endotoxemia.​

Preclinical and emerging clinical evidence

• Obese‑mouse studies from groups at Texas Tech/University of Missouri report better glucose tolerance, improved insulin sensitivity, lower leptin, MCP‑1 and IL‑6, and improved bone microstructure with geranylgeraniol supplementation.​

• Human and mechanistic data suggest GG can restore GGPP, support endogenous CoQ10 synthesis, and help reverse statin‑associated muscle symptoms (SAMS), where CoQ10 alone has often been insufficient.​

Result: GG helps address metabolic dysfunction (insulin resistance) and mitochondrial energy deficits, counteracts statin‑related depletion of mevalonate intermediates and supports musculoskeletal and immune‑metabolic health as part of a broader strategy for cardiometabolic and cancer risk reduction.

Why T3 + GG Together?

Tocotrienol is a powerhouse antioxidant on its own, but adding geranylgeraniol (GG) amplifies the benefits significantly. While T3 protects cells from free radical damage, GG restores the cellular energy your body needs to repair and regenerate. Together, they create a complete cellular defence system that works at every level - protection and regeneration.

The unique power duo - DeltaGold™ Tocotrienol E (ARTG 373033) and GG-Gold™ encapsulated together into one capsule. Powerful, convenient, effective.

#1 Choice

Why Together? The Synergistic Cycle-Breaker

Tocotrienols help reduce oxidative stress and chronic inflammation at the cellular level and have been shown to modulate insulin‑related and cancer‑related signalling, including NF‑κB and PI3K/Akt pathways. This supports healthier insulin signalling and reduces several pro‑tumour survival signals, but cells can still struggle if mitochondrial energy production is compromised – a common issue in insulin‑resistant states and in people taking statins, which lower mevalonate‑pathway intermediates needed for CoQ10.​

Geranylgeraniol helps restore this energy infrastructure by replenishing geranylgeranyl pyrophosphate (GGPP), a precursor needed for CoQ10 synthesis and proper prenylation of small GTPases involved in mitochondrial and metabolic function. Experimental data also suggest that geranylgeraniol can favourably influence insulin sensitivity and adipocyte biology through PPAR‑related and GGPP‑dependent signalling.​

Together, this duo creates a more comprehensive intervention that addresses all three pillars of the root‑cause triad – oxidative stress, chronic inflammation and metabolic dysfunction (insulin resistance) – rather than targeting a single downstream marker in isolation.

Annatto geranylgeraniol (GG) – insulin sensitivity + energy support

GG is a mevalonate‑pathway intermediate that the body converts to geranylgeranyl pyrophosphate (GGPP), which participates in two critical processes:​

• Endogenous CoQ10 support: GG provides substrate for GGPP, which is required for the synthesis of the CoQ10 side chain, enabling mitochondria to maintain their own CoQ10 levels for electron transport and ATP production, particularly when the mevalonate pathway is partially blocked by statins.​

• Protein prenylation & signalling: GGPP geranylgeranylates small GTPases (Ras, Rho, Rac and others) that are essential for membrane localisation and signalling in pathways governing metabolism, insulin action and cell survival.​

• PPARγ modulation: Experimental work shows geranylgeraniol increases PPARγ expression and enhances PPARγ‑driven adipocyte biology, a mechanism linked with improved insulin sensitivity in adipose tissue. This also influences adipokines such as leptin and MCP‑1 that connect fat tissue to systemic inflammation.​

• Gut microbiome effects: In obese mouse models, dietary geranylgeraniol improved glucose homeostasis, reduced pro‑inflammatory adipokines and altered the gut microbiome, including increases in beneficial butyrate‑producing bacteria and reductions in taxa associated with obesity‑related metabolic dysfunction, helping to address metabolic endotoxemia.​

Preclinical and emerging clinical evidence

• Obese‑mouse studies from groups at Texas Tech/University of Missouri report better glucose tolerance, improved insulin sensitivity, lower leptin, MCP‑1 and IL‑6, and improved bone microstructure with geranylgeraniol supplementation.​

• Human and mechanistic data suggest GG can restore GGPP, support endogenous CoQ10 synthesis and help reverse statin‑associated muscle symptoms (SAMS), where CoQ10 alone has often been insufficient.​

Result: GG helps address metabolic dysfunction (insulin resistance) and mitochondrial energy deficits, counteracts statin‑related depletion of mevalonate intermediates and supports musculoskeletal and immune‑metabolic health as part of a broader strategy for cardiometabolic and cancer risk reduction.

Why You Haven't Heard of This

The research is real. The evidence is solid. Clinical trials are ongoing at major universities. So why isn't your doctor recommending these compounds?

REASON 1: Compounds are natural
Can't be patented. No profit motive for massive pharmaceutical-scale marketing campaigns.

REASON 2: Research is spread globally
Victoria University (Australia), Monash University (Australia), Texas Tech, University of Missouri, NIH, dozens of research institutions worldwide. No single organisation connecting the dots for mainstream medicine.

REASON 3: Medical education lags behind research
These compounds aren't in medical school curriculum yet. Doctors learn what was considered standard practice 20 years ago.

REASON 4: Most supplement companies use hype instead of evidence
We refuse to do that. Everything we say is backed by peer-reviewed research from respected institutions.

BOTTOM LINE

You have access to compounds with clinical evidence supporting their use for disease prevention and treatment BEFORE mainstream medicine catches up.

The barriers aren't scientific, they're economic and institutional.

Tocotrienol

VICTORIA UNIVERSITY META-ANALYSIS (2022)

• Published: BioFactors (peer-reviewed journal)

• Authors: Ranasinghe, Mathai & Zulli (leading researchers)

• Scope: Analysis of 300+ peer-reviewed studies

• Coverage: Cardiovascular, neurological, metabolic, hepatic, renal, immune and bone health, across multiple disease states

• Regulatory Approval: TGA listing for DeltaGold™ (ARTG 373033, approved as medicine in Australia)

Key Finding: Consistent evidence across multiple organ systems showing tocotrienol's antioxidant, anti-inflammatory and cellular protective effects.

Geranylgeraniol

RESEARCH FROM MULTIPLE UNIVERSITIES

• Texas Tech University: Glucose and bone health studies

• University of Missouri: Cardiovascular and metabolic research

• NIH Clinical Trials: Ongoing studies in inflammatory disorders, sexual health, testosterone production

• Published in: Nature, Journal of Clinical Pharmacology, Nutrients, Frontiers in Nutrition, multiple peer-reviewed journals

• Safety Status: GRAS (Generally Recognized As Safe) by FDA standards

Active Clinical Trials

• Mevalonate kinase deficiency (inflammatory disorder), ongoing at NIH

• Sexual health function, randomised, double-blind, placebo-controlled trial

• Testosterone production in middle-aged men, ongoing

• Diabetic neuropathy pain management. published 2025

The Research Behind Both Compounds

What The Experts Say

DR. BARRIE TAN
Annatto Research Pioneer

"Each day it is becoming increasingly understood that tocotrienols (especially delta-tocotrienols) are the right form of vitamin E. Well in excess of 100 studies and clinical trials have shown the surprising benefits of tocotrienols – without any known side effects. These studies show that tocotrienols, combined with a healthy lifestyle, do incredible things including lowering lipids, reducing inflammation, protecting the liver, promoting bone health, killing cancer cells and even increasing survival rates in cancer patients."

DR. JOSEPH KEENAN
University of Minnesota, Minneapolis, USA

"Tocotrienols have really come to the fore as an agent that might be quite important in preventing cancer. It's also been shown to be helpful in preventing other problems: ageing, inflammatory diseases, vascular diseases we've seen in the stroke setting..."

DR. RON MITTLER
Curators' Distinguished Professor at the University of Missouri, USA.

“...because we're living in an oxygenic atmosphere ROS and oxidative stress have been associated with almost all diseases that you can think of.”

Questions About These Supplements

"For all its merits, it would be a fitting tribute to qualify tocotrienol as mother nature’s gift to the brain." Role of Micronutrients in Brain Health (Chapter 5, Pages 69–88)

• Ahmad Farouk Musa, Cheang Jia Min, and Christina Gertrude Yap (Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia).

✅ DeltaGold™ Tocotrienol is on the Australian Register of Therapeutic Goods (ARTG 373033) - category: 'medicine'

✅ USA FDA GRAS Certified Ingredients - Our T3 and GG have FDA recognition as safe and effective

✅ cGMP Certified Manufacturing - Every batch produced under FDA-enforced quality standards

✅ 300+ peer-reviewed studies (Victoria Uni., Monash Uni., ++)

✅ The #1 Selling Vitamin E Recommended by Dr Barrie Tan Ph.D.

✅ Manufacturing Partner - Wellness Extract - 100,000+ customers. Satisfaction Rating 4.85/5.00

Here's what the science reveals and what you can do about it:

Oxidative stress + Chronic Inflammation = The root cause of ageing and disease (The "Deadly Cycle").

(ROS = Reactive Oxygen Species. When antioxidant protection is low, they create oxidative stress.)

✅ 100% Interference-Free Absorption
Unlike palm or rice sources, our Annatto is Tocopherol-Free. This prevents the "blocking effect" common in other Vitamin E supplements, ensuring your body absorbs 100% of the potent tocotrienols.

✅ 50x Faster Cellular Protection
Delta-Tocotrienols are smaller and more agile than standard Vitamin E, moving through cell membranes 50x faster to fight oxidative stress and inflammation where it matters most.

✅ The "Spark Plug" for Cellular Energy
Includes GG-Gold™ (Geranylgeraniol), the critical nutrient your body needs to synthesise its own CoQ10, fueling heart health and preventing age-related muscle loss.

✅ Total Metabolic Defence
Clinically shown to target the root of metabolic illness by supporting healthy cholesterol levels, blood sugar sensitivity and liver function simultaneously.

✅ Medical-Grade Safety Profile
DeltaGold™ is listed on the Australian Register of Therapeutic Goods (ARTG 373033) and both compounds hold USA FDA GRAS status, guaranteeing safety and quality.

✅ Free Shipping Within Australia

Via Australia Post standard parcel service.

✅ Australian Owned & Operated
"My Mum died of dementia. Two other relatives died of MND. That's why we started this site. I wish I had known about these amazing natural supplements earlier." - Alexander

The Wellness Extract Difference

• LIPID-SOLUBLE POWERHOUSE

  Annatto tocotrienol penetrates cell membranes.

• CROSS-BARRIER PROTECTION
  Proven to reach mitochondria & brain cells.

• DOUBLE SHIELD FORMULA
  Geranylgeraniol + tocotrienol locks out ROS

• DIET FRIENDLY ACTIVE INGREDIENTS +

  Gluten free; Sugar free; Nuts free; Soy free; Emulsion free; Tocopherol free; Non GMO; Kosher - However not strictly vegan as the gelcaps are made from bovine gelatin.

• DeltaGold™ Tocotrienol is Included on the Australian Register of Therapeutic Goods (ARTG 373033) in the category: 'medicine'.

"Tocotrienols have really come to the fore as an agent that might be quite important in preventing cancer. It's also been shown to be helpful in preventing other problems: ageing, inflammatory diseases, vascular diseases we've seen in the stroke setting..."

- Dr. Joseph Keenan, of University of Minnesota, Minneapolis, USA

The Power of 'Eannatto' Tocotrienol

Containing the Purest and Most Potent Form of Tocotrienol: DeltaGold®

DeltaGold™ is free from any artificial flavors, or preservatives, making it a wholesome choice for individuals seeking optimal nutrition.

DeltaGold™ is approved by the TGA of Australia (ARTG 373033) as 'medicine'.

Download Dr Barrie Tan's book, "The Truth About Vitamin E" for free. Obtain a better understanding of the benefits of tocotrienol and the interesting story behind his amazing discovery of Annatto Tocatrienol.

Rigorous Systematic Review of Tocotrienol Therapeutics

Image courtesy of Victoria Univerity Research, Melbourne, Australia

Evidence‑Based Insights from 300+ Studies

In the comprehensive 2022 review article “Revisiting the Therapeutic Potential of Tocotrienols,” Ranmali Ranasinghe, Michael Mathai, and Anthony Zulli of Victoria University, Melbourne, Australia, systematically evaluated findings from over 300 peer‑reviewed studies to delineate tocotrienols’ effects across diverse organ systems VU ResearchVU Research. Their analysis highlights tocotrienols’ potent antioxidant, anti‑inflammatory, and cellular regulatory functions in the cardiovascular, neurological, hepatic, renal, and integumentary systems, as depicted in the below diagrams. To explore the detailed methodology, data synthesis, and clinical implications, we invite you to read the full report published in BioFactors via the link VU Research.

Image courtesy of Victoria Univerity Research, Melbourne, Australia

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