Our Essential Endogenous Molecule

Geranylgeraniol

Geranylgeraniol (GG) is an endogenous nutrient in our body that declines as we age. It is essential for protein synthesis and the production of testosterone, progesterone, CoQ10 and MK4. It may also help with the management of sarcopenia. Extracted from the annatto plant, GG-Gold® replenishes GG levels lost due to ageing or pharmaceutical drugs (cholesterol-lowering statins in particular). Daily use of GG-Gold® will help promote normal energy levels and allow you to age gracefully*.

American River Nutrition. (n.d.). GG-Gold®. Retrieved September 28, 2025, from https://americanrivernutrition.com/products/gg-gold/

Functions of GG in the Body

GG is involved in:

1 Prenylation of Proteins:

GG enables the attachment of proteins, such as Ras, Rho, and Rab, to cell membranes, facilitating their role in cellular signalling, immune responses, and cytoskeletal organisation.

2. Synthesis of Coenzyme Q10 (CoQ10):

GG is a precursor for CoQ10, a key molecule in mitochondrial energy production and an antioxidant that protects cells from oxidative stress.

3. Production of Heme A:

GG contributes to the formation of heme A, an essential part of mitochondrial respiratory enzymes like cytochrome c oxidase, which drives ATP production.

4. Steroid Hormone Biosynthesis:

GG is crucial in the synthesis of cholesterol, a precursor for steroid hormones, including testosterone, estrogen, and cortisol.

5. Bone Health:

GG supports bone health by stimulating osteoblast (bone-forming cell) activity and reducing osteoclast (bone-resorbing cell) activity.

6. Vitamin K Activation:

GG aids in the activation of Vitamin K-dependent proteins, which are crucial for blood clotting and preventing vascular calcification.

Why is GG Important

GG is critical for maintaining cellular function and overall health. A deficiency can lead to:

• Impaired Protein Function: Disrupted cell signalling and immune regulation.

• Energy Deficiency: Fatigue and muscle weakness due to reduced CoQ10.

• Bone Weakness: Increased risk of osteoporosis and bone fractures.

• Hormonal Imbalances: Decreased production of testosterone another steroid hormones.

Impact of Statins on GG Levels

Statins, used to lower cholesterol, inhibit the enzyme HMG-CoA reductase in the mevalonate pathway. This reduces cholesterol production but also decreases GG synthesis. As a result:

• Prenylation of proteins is impaired, affecting cellular functions.

• CoQ10 levels drop, leading to energy deficits and muscle pain (statin-induced myopathy).

• Bone health and hormone production are negatively affected.

Supplementing GG

Geranylgeraniol supplements are being studied for their ability to:

• Mitigate statin side effects.

• Support bone and muscle health.

• Enhance hormone production.

GG is often combined with tocotrienols (a form of vitamin E) to provide synergistic benefits in addressing oxidative stress, inflammation, and metabolic health.

Why Choose Annatto GG?

Annatto-derived GG is a pure, plant-based source, free from synthetic additives. It is extracted from the seeds of the annatto plant (Bixa orellana), offering a natural and potent way to restore your body’s GG levels safely and effectively. Geranylgeraniol - The Unsung Hero of Nutrient Absorption?

Take Control of Your Health Today

Whether you're managing the effects of aging or seeking relief from statin-related side effects, adding GG to your daily routine can make a transformative difference. Support your cellular health, protect your muscles, and sustain your energy with this essential nutrient.

Explore our range of GG supplements at Natural Health Connect, including the powerful Eannatto™ GG Essential and combined formulations like Eannatto™ 150+ to maximize your health benefits.

Disclaimer

The information provided in this Health Hub is for educational and informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be regarded as a substitute for professional medical advice. Always consult with a qualified healthcare provider before making any decisions regarding your health, supplements, or treatment options. While every effort is made to ensure accuracy, Natural Health Connect makes no guarantees about the completeness or reliability of the information presented.