We're excited to share the latest evidence-based information about these two remarkable natural compounds that can significantly impact your health: annatto tocotrienol (DeltaGold™) and geranylgeraniol (GG-Gold®). These compounds, derived from the annatto plant, represent a powerful combination for preventing and managing various health conditions.

What is Annatto Tocotrienol?

Annatto tocotrienol, specifically the DeltaGold™ variety, is the most potent form of vitamin E available today. Unlike the common alpha-tocopherol found in most vitamin E supplements, annatto tocotrienol contains 90% delta-tocotrienol and 10% gamma-tocotrienol - the most biologically active forms of vitamin E. This unique composition makes it 50 times more powerful as an antioxidant compared to traditional vitamin E [1, 2].

What is Geranylgeraniol?

Geranylgeraniol (GG) is a vital isoprenoid compound essential for producing CoQ10, vitamin K2 (MK4), and supporting crucial cellular processes. Our bodies need adequate GG levels for optimal energy production, testosterone synthesis, and bone health [3, 4. 5. 6].

Recommended Dosages Based on Health Status

For Healthy Individuals (Prevention)

Starting recommendation: Eannatto® DeltaGold™ 150+ - one gel capsule daily with your evening meal

. Each capsule provides:

• 150mg DeltaGold™ tocotrienol

• 75mg GG-Gold® geranylgeraniol

This 2:1 ratio of tocotrienol to geranylgeraniol provides optimal synergistic benefits for general health maintenance [7, 8].

For Mild Existing Conditions

Start with the same dose as healthy individuals, but consider increasing to one capsule twice daily (with breakfast and dinner) if needed [7]. This provides:

• 300mg total tocotrienol daily

• 150mg total geranylgeraniol daily

For Advanced Chronic Conditions

Dosage may need to be increased to 450-600mg tocotrienol daily, split across multiple meals [7]. At this level, individual products may be necessary to achieve optimal ratios.

Individual Product Options for Customized Dosing

When specific ratios are needed or higher doses are required:

Eannatto® DeltaGold™ Tocotrienol Only

• Available in 125mg or 300mg gel capsules

• 60 capsules per pack

• Use when higher tocotrienol concentrations are needed [17].

GG-Essential

• Contains 150mg pure annatto-derived GG-Gold®

• Use when increased geranylgeraniol focus is required

• Can be combined with tocotrienol products as needed [5].

Condition-Specific Dosing Guidelines

Cardiovascular Health

• Cholesterol management: 250mg tocotrienol daily [10, 11, 12].

• General heart health: 150-300mg tocotrienol + 75-150mg GG daily [11, 13].

• Advanced cardiovascular disease: Up to 600mg tocotrienol daily [10, 12].

Bone Health

• Prevention: 300mg tocotrienol daily [17].

• Osteopenia/osteoporosis support: 300-600mg tocotrienol daily [14, 15].

• Always combine with adequate vitamin D and vitamin K2.

Liver Health

• Fatty liver disease: 600mg tocotrienol daily (300mg twice daily) [10, 16, 17].

• Liver support: 300-450mg tocotrienol daily [16].

Metabolic Support

• Diabetes/pre-diabetes: 250-400mg tocotrienol + 150-300mg GG daily [10, 16].

• Weight management: 300mg tocotrienol daily [16].

Cognitive Health

• Brain protection: 200-400mg tocotrienol daily [18].

• Neuroprotection: 300mg tocotrienol + 150mg GG daily [18].

Critical Timing and Absorption Guideline

Meal Timing is Essential

Always take with meals - tocotrienol is fat-soluble and absorption increases 2-3 fold when taken with food compared to fasting [7, 19, 20]. The presence of dietary fats triggers bile secretion, which dramatically improves absorption [19].

Maximum Single Dose Rule

Never exceed 300mg tocotrienol in a single dose [7, 21]. Research clearly shows that doses above 300mg at one time do not provide additional benefits [7]. For daily totals exceeding 300mg, always split across multiple meals [7].

Best Timing

• Single daily dose: Take with your largest meal (typically dinner) [7]

• Split dosing: Take with breakfast and dinner for optimal absorption [7].

Safety Profile - Exceptional Safety Record

Clinical Safety Data

Extensive clinical trials demonstrate remarkable safety [22, 23]:

• Up to 600mg daily for 12 weeks: No adverse effects on liver or kidney function [1, 10]

• Up to 900mg daily for 24 months: Safely tolerated [7]

• Even up to 1,600mg daily: No serious adverse effects in clinical trials [23].

Geranylgeraniol Safety

• 150mg daily: Well-tolerated with minimal side effects [5]

• 300mg daily: Safe in clinical trials [5. 6]

• Up to 725mg/kg body weight: Determined as safe in animal studies [5].

FDA Recognition

• DeltaGold™: FDA-affirmed GRAS (Generally Recognized as Safe) status [24. 25]

• Annatto extracts: Long history of safe use as food additives [25].

Australian Therapeutic Goods Administration (TGA)

• DeltaGold™ Tocotrienol E: (ARTG 373033)

• Permitted Indications:

  • Antioxidant/Reduce free radicals formed in the body

  • Helps reduce/decrease free radical damage to body cells

  • Anti-inflammatory/relieve inflammation

  • Helps maintain/support healthy cholesterol

  • Maintain/support cardiovascular system health.

• Approved Area:

  • Listed Medicines

Important Considerations and Interactions

Alpha-Tocopherol Interference

Critical warning: Regular alpha-tocopherol (common vitamin E) supplements can completely block tocotrienol benefits [7, 21]. When alpha-tocopherol comprises more than 15% of total vitamin E intake, it interferes with tocotrienol function. However, dietary alpha-tocopherol from food sources does not cause interference [7].

Drug Interactions

• Generally safe with most medications [22]

• Statins: GG may actually help reduce statin-related muscle pain [3]

• Always consult your healthcare provider before starting, especially if taking multiple medications.

Special Populations

• Pregnancy/breastfeeding: Consult healthcare provider before use [22]

• Children: Dosing not established in pediatric populations

• Chronic conditions: Work with healthcare provider to optimize dosing

Why This Combination Works So Well

The synergistic relationship between tocotrienol and geranylgeraniol creates benefits neither compound achieves alone [3, 4]:

1. Enhanced cellular energy production [3, 4]

2. Improved antioxidant protection [1, 2]

3. Better cardiovascular support [11, 13, 26]

4. Optimized bone and joint health [14, 15]

5. Superior metabolic regulation [10, 16]

Monitoring Your Progress

What to Expect

• Weeks 1-4: Initial cellular protection begins

• Months 1-3: Energy levels and general well-being improvements

• Months 3-6: Measurable changes in biomarkers (cholesterol, inflammation markers) [10, 11, 13].

• 6+ months: Optimal benefits for long-term health protection.

Regular Health Monitoring

Consider tracking:

• Lipid profiles (cholesterol, triglycerides) [10,11,12]

• Inflammatory markers (C-reactive protein) [10, 11]

• Blood pressure and blood glucose [10, 16]

• Bone density (if relevant to your health goals) [14, 15].

Observations

The research is solid, the safety profile is exceptional, and the benefits are real. What impresses us most is how these natural compounds address multiple health concerns simultaneously - something traditional medicine often struggles to achieve safely.

The key to success is consistency, proper dosing, and patience. These are not quick fixes but powerful tools for long-term health optimisation. Start with the basic Eannatto® DeltaGold™ 150+ formula, take it religiously with your evening meal, and give your body time to respond.

Remember, these supplements work best as part of a comprehensive approach to health that includes proper nutrition, regular exercise, stress management, and adequate sleep. They're powerful allies in your health journey, but they work best when combined with other healthy lifestyle choices.

Always consult with a qualified healthcare provider before starting any new supplement regimen, especially if you have existing health conditions or take medications. This information is for educational purposes and should not replace professional medical advice.

References

1. Braun, K. F., et al. (2018). A 12-week evaluation of annatto tocotrienol supplementation for postmenopausal women with osteopenia. PubMed. https://pubmed.ncbi.nlm.nih.gov/29954374/

2. Dr. Barrie Tan FAQ. (2022). Why Tocotrienol. https://barrietan.com/why-tocotrienol/faq/

3. American River Nutrition. (2022). Annatto Tocotrienol Improves Glycemic Control in Patients with Type 2 Diabetes Mellitus. https://americanrivernutrition.com/annatto-tocotrienol-improves-glycemic-control-in-patients-with-type-2-diabetes-mellitus-2/

4. Tan, B. (2019). Using Tocotrienols to Address Lifestyle and Metabolic Disease. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC6601449/

5. American River Nutrition. (2024). Geranylgeraniol Supplementation May Benefit Males with Low Testosterone. https://americanrivernutrition.com/geranylgeraniol-supplementation-may-benefit-males-with-low-testosterone-clinical-study/

6. Tocotrienols Australia FAQ. Tocotrienols. https://tocotrienols.com.au/index.php/why-tocotrienol/faq

7. Designs for Health. Tocotrienols- The New Vitamin E with Dr Barrie Tan. https://designsforhealth.com.au/tocotrienols-the-new-vitamin-e-with-dr-barrie-tan/

8. Prasad, K. (2011). Tocotrienols and cardiovascular health. PubMed. https://pubmed.ncbi.nlm.nih.gov/21774782/

9. Trugilho, L., et al. (2025). Effects of Tocotrienol on Cardiovascular Risk Markers in Patients with Chronic Kidney Disease. PubMed. https://pubmed.ncbi.nlm.nih.gov/39840146/

10. Qureshi, A. A., et al. (1999). Tocotrienol: a review of its therapeutic potential. ScienceDirect. https://www.sciencedirect.com/science/article/abs/pii/S0009912099000272

11. Pervez, M. A., et al. (2023). Tocotrienol in the Management of Nonalcoholic Fatty Liver Disease. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC9965814/

12. Ibrahim, N., et al. (2018). Tocotrienols Regulate Bone Loss through Suppression on Osteoclastogenesis. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC6094554/

13. Nutraceutical Business Review. (2023). Tocotrienol for cardiovascular health: the superior vitamin E form. https://nutraceuticalbusinessreview.com/tocotrienol-cardiovascular-health-vitamin-E-heart-health

14. BMJ. (2019). IDDF2019-ABS-0194 The role of tocotrienols in the treatment of non-alcoholic steatohepatitis. https://gut.bmj.com/content/68/Suppl_1/A144.1

15. Dovepress. The biological effects of tocotrienol on bone: a review on evidence from preclinical studies. https://www.dovepress.com/the-biological-effects-of-tocotrienol-on-bone-a-review-on-evidence-fro-peer-reviewed-fulltext-article-DDDT

16. Applied Science & Performance Institute. (2023). The Effects of Geranylgeraniol on Blood Safety and Sex Hormone Profiles in Healthy Adults. MDPI. https://www.mdpi.com/1661-3821/3/4/43

17. MedRxiv. (2024). Geranylgeraniol supplementation leads to an improvement in inflammatory parameters. https://www.medrxiv.org/content/10.1101/2024.07.17.24309492v1.full.pdf

18. Phang, S. C. W., et al. (2021). Tocotrienol-Rich Vitamin E (Tocovid) Improved Nerve Conduction Velocity. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC8618591/

19. Monash University Research. An Underrated Isomer of Vitamin E in Health and Diseases. https://research.monash.edu/files/410025381/409673207.pdf

20. Monash University Research. (2021). Tocotrienol-Rich Vitamin E (Tocovid) Improved Nerve Conduction Velocity. https://research.monash.edu/files/419169134/398697040_oa.pdf

21. Ikeda, S., et al. (2012). Tissue distribution of α- and γ-tocotrienol and γ-tocopherol in rats. PubMed. https://pubmed.ncbi.nlm.nih.gov/22042641/

22. Husain, K., et al. (2016). Pharmacokinetics and Safety of Vitamin E δ-Tocotrienol after Single and Multiple Dose Administrations. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC4939900/

23. Nutraceutical Business Review. (2025). American River Nutrition's DeltaGold receives FDA GRAS status. https://nutraceuticalbusinessreview.com/american-river-nutrition-s-deltagold-receives-fda-gras-status-99424

24. Yap, S. P., et al. (2001). Pharmacokinetic characteristics of alpha-, gamma- and delta-tocotrienols under different food status. PubMed. https://pubmed.ncbi.nlm.nih.gov/11206194/

25. Food Safety. (2023). FDA Updates on Chemical Safety Reassessment Work. https://www.food-safety.com/articles/8732-fda-updates-on-chemical-safety-reassessment-work-reveals-substances-of-agencys-focus

26. Yap, S. P., et al. (2014). Bioavailability of tocotrienols: evidence in human studies. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC3895660/

27. Phang, S. C. W., et al. (2023). Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC10509396/

28. Monash University Research. Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes. https://researchmgt.monash.edu/ws/portalfiles/portal/567569060/501747019_oa.pdf

29. Pervez, M. A., et al. (2021). Effects of delta-tocotrienol supplementation on Glycemic Control. PubMed. https://pubmed.ncbi.nlm.nih.gov/33899292/

30. Pervez, M. A., et al. (2018). Effects of delta-tocotrienol supplementation on liver enzymes in patients with NAFLD. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC6284694/

31. CenterWatch. (2025). A Crossover Clinical Trial Investigating the Effects of Geranylgeraniol Supplementation on Testosterone Levels. https://www.centerwatch.com/clinical-trials/listings/NCT06747624/a-crossover-clinical-trial-investigating-the-effects-of-geranylgeraniol-gg-supplementation-on-testosterone-levels-in-healthy-men-and-women-over-an-18-week-period

32. American River Nutrition. (2022). Annatto Tocotrienol Improves Fatty Liver and Hepatic Steatosis in Patients with NAFLD. https://americanrivernutrition.com/annatto-tocotrienol-improves-fatty-liver-and-hepatic-steatosis-in-patients-with-non-alcoholic-fatty-liver-disease-nafld/

Understanding These Natural Powerhouses