We're excited to share the latest evidence-based information about these two remarkable natural compounds that can significantly impact your health: annatto tocotrienol (DeltaGold™) and geranylgeraniol (GG-Gold®). These compounds, derived from the annatto plant, represent a powerful combination for preventing and managing various health conditions.

What is Annatto Tocotrienol?

Annatto tocotrienol, specifically the DeltaGold™ variety, is the most potent form of vitamin E available today. Unlike the common alpha-tocopherol found in most vitamin E supplements, annatto tocotrienol contains 90% delta-tocotrienol and 10% gamma-tocotrienol – the most biologically active forms of vitamin E. This unique composition makes it up to 50 times more powerful as an antioxidant compared with traditional vitamin E.

What is Geranylgeraniol (GG)?

Geranylgeraniol (GG) is a vital isoprenoid compound essential for producing CoQ10 and vitamin K2 (MK4), while supporting multiple crucial cellular processes. Adequate GG levels are necessary for optimal energy production, testosterone synthesis, and bone health.

Recommended Dosages Based on Health Status

For Healthy Individuals (Prevention)

Starting recommendation:

• Eannatto® DeltaGold™ 150+ – one gel capsule daily with your evening meal.

Each capsule provides:

• 150mg DeltaGold™ tocotrienol

• 75mg GG-Gold® geranylgeraniol

This 2:1 ratio of tocotrienol to geranylgeraniol provides optimal synergistic benefits for general health maintenance.

For Mild Existing Conditions

• Begin with the same dose as for healthy individuals.

• If additional support is needed, increase to one capsule twice daily (with breakfast and dinner).

This provides a daily total of:

• 300mg tocotrienol

• 150mg geranylgeraniol

For Advanced Chronic Conditions

Dosage may need to be increased to 450–600mg tocotrienol daily, split across multiple meals. Taking more than 300mg tocotrienol at any one time does not increase effectiveness (Dr. Barrue Tan).

At this level, individual products may be required to achieve precise ratios.

Individual Product Options for Customised Dosing

• Eannatto® DeltaGold™ Tocotrienol Only

  • Available in 125mg or 300mg gel capsules

  • Used when higher tocotrienol concentrations are needed

• GG-Essential

  • Contains 150mg pure annatto-derived GG-Gold®

  • Ideal when increased geranylgeraniol focus is required

  • Can be combined with tocotrienol products as needed

Condition-Specific Dosing Guidelines

Cardiovascular Health

• Cholesterol management: 250mg tocotrienol daily

• General heart health: 150–300mg tocotrienol + 75–150mg GG daily

• Advanced cardiovascular disease: Up to 600mg tocotrienol daily.

Bone Health

• Prevention: 300mg tocotrienol daily

• Osteopenia/osteoporosis support: 300–600mg tocotrienol daily

• Always combine with vitamin D and vitamin K2.

Liver Health

• Fatty liver disease: 600mg tocotrienol daily (300mg twice daily)

• General liver support: 300–450mg tocotrienol daily.

Metabolic Support

• Diabetes / pre-diabetes: 250–400mg tocotrienol + 150–300mg GG daily

• Weight management: 300mg tocotrienol daily.

Cognitive Health

• Brain protection: 200–400mg tocotrienol daily

• Neuroprotection: 300mg tocotrienol + 150mg GG daily.

Critical Timing and Absorption Guidelines

• Always take with meals – tocotrienol is fat-soluble and absorption increases 2–3 fold with food.

• Do not exceed 300mg in a single dose. Split higher daily totals between meals for maximum effect.

• Best timing:

  • Single daily dose → take with your largest meal (typically dinner)

  • Split dosing → breakfast and dinner for more even absorption

Pharmacokinetics:

• 125–250mg → Tmax ≈ 3 hours

• 500mg → Tmax ≈ 6 hours

• Half-life: short (~1.4–2.5h), supporting the case for split dosing.

Safety Profile

• Clinical trials confirm excellent safety:

  • Up to 600mg daily for 12 weeks – no adverse effects

  • Up to 900mg daily for 24 months – safely tolerated

  • Even up to 1,600mg daily – no serious adverse events.

• GG safety:

  • 150–300mg daily well tolerated

  • Animal studies confirm high safety margins

• FDA GRAS recognition for DeltaGold™ tocotrienol

• TGA listing (ARTG 373033) with approved claims for antioxidant, anti-inflammatory, cardiovascular, and cholesterol support.

Important Considerations

• Avoid alpha-tocopherol supplements (they interfere with tocotrienol’s benefits).

• Medication interactions: generally safe, though GG may help reduce statin-related muscle pain.

• Special populations:

  • Pregnancy & breastfeeding → consult a healthcare provider.

  • Children → no established dosing.

  • Chronic conditions → best managed under a clinician or naturopathic doctor’s guidance.

Why This Combination Works So Well

The synergy of tocotrienol + GG creates benefits neither achieves alone:

• Enhanced cellular energy production

• Stronger antioxidant defence

• Cardiovascular support

• Bone and joint protection

• Metabolic regulation.

Monitoring Your Progress

• Weeks 1–4: Early cellular protection

• Months 1–3: Improved energy and well-being

• Months 3–6: Biomarker improvements (cholesterol, CRP, glucose)

• 6+ months: Sustained benefits for long-term health.

What to track:

• Lipids (cholesterol, triglycerides)

• Inflammatory markers (CRP)

• Blood pressure & glucose

• Bone density (if relevant).

Key Takeaways

• Annatto tocotrienol and geranylgeraniol are safe, potent, and synergistic nutrients with exceptional research support.

• Results come from consistency, proper dosing, and patience – these are long-term health optimisers, not quick fixes.

• Best results are achieved when integrated into a healthy lifestyle: balanced diet, exercise, stress management, and sleep.

• For chronic conditions or advanced dosing, always seek guidance from a qualified healthcare professional or naturopathic doctor.

Observations

The research is solid, the safety profile is exceptional, and the benefits are real. What impresses us most is how these natural compounds address multiple health concerns simultaneously - something traditional medicine often struggles to achieve safely.

The key to success is consistency, proper dosing, and patience. These are not quick fixes but powerful tools for long-term health optimisation. Start with the basic Eannatto® DeltaGold™ 150+ formula, take it religiously with your evening meal, and give your body time to respond.

Remember, these supplements work best as part of a comprehensive approach to health that includes proper nutrition, regular exercise, stress management, and adequate sleep. They're powerful allies in your health journey, but they work best when combined with other healthy lifestyle choices.

Always consult with a qualified healthcare provider before starting any new supplement regimen, especially if you have existing health conditions or take medications. This information is for educational purposes and should not replace professional medical advice.

References

1. Shen, C-L., Mo, H., Dunn, D. M., Watkins, B. A., et al. (2021). Tocotrienol Supplementation Led to Higher Serum Levels of Lysophospholipids but Lower Acylcarnitines in Postmenopausal Women: A Randomized Double-Blinded Placebo-Controlled Clinical Trial. Frontiers in Nutrition, 8, Article 766711. https://www.frontiersin.org/articles/10.3389/fnut.2021.766711/full

2. Braun, K. F., et al. (2018). A 12-week evaluation of annatto tocotrienol supplementation for postmenopausal women with osteopenia. PubMed. https://pubmed.ncbi.nlm.nih.gov/29954374/

3. Dr. Barrie Tan FAQ. (2022). Why Tocotrienol. https://barrietan.com/why-tocotrienol/faq/

4. American River Nutrition. (2022). Annatto Tocotrienol Improves Glycemic Control in Patients with Type 2 Diabetes Mellitus. https://americanrivernutrition.com/annatto-tocotrienol-improves-glycemic-control-in-patients-with-type-2-diabetes-mellitus-2/

5. Tan, B. (2019). Using Tocotrienols to Address Lifestyle and Metabolic Disease. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC6601449/

6. American River Nutrition. (2024). Geranylgeraniol Supplementation May Benefit Males with Low Testosterone. https://americanrivernutrition.com/geranylgeraniol-supplementation-may-benefit-males-with-low-testosterone-clinical-study/

7. Tocotrienols Australia FAQ. Tocotrienols. https://tocotrienols.com.au/index.php/why-tocotrienol/faq

8. Prasad, K. (2011). Tocotrienols and cardiovascular health. PubMed. https://pubmed.ncbi.nlm.nih.gov/21774782/

9. Trugilho, L., et al. (2025). Effects of Tocotrienol on Cardiovascular Risk Markers in Patients with Chronic Kidney Disease. PubMed. https://pubmed.ncbi.nlm.nih.gov/39840146/

10. Qureshi, A. A., et al. (1999). Tocotrienol: a review of its therapeutic potential. ScienceDirect. https://www.sciencedirect.com/science/article/abs/pii/S0009912099000272

11. Pervez, M. A., et al. (2023). Tocotrienol in the Management of Nonalcoholic Fatty Liver Disease. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC9965814/

12. Ibrahim, N., et al. (2018). Tocotrienols Regulate Bone Loss through Suppression on Osteoclastogenesis. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC6094554/

13. Nutraceutical Business Review. (2023). Tocotrienol for cardiovascular health: the superior vitamin E form. https://nutraceuticalbusinessreview.com/tocotrienol-cardiovascular-health-vitamin-E-heart-health

14. BMJ. (2019). IDDF2019-ABS-0194 The role of tocotrienols in the treatment of non-alcoholic steatohepatitis. https://gut.bmj.com/content/68/Suppl_1/A144.1

15. Applied Science & Performance Institute. (2023). The Effects of Geranylgeraniol on Blood Safety and Sex Hormone Profiles in Healthy Adults. MDPI. https://www.mdpi.com/1661-3821/3/4/43

16. MedRxiv. (2024). Geranylgeraniol supplementation leads to an improvement in inflammatory parameters. https://www.medrxiv.org/content/10.1101/2024.07.17.24309492v1.full.pdf

17. Phang, S. C. W., et al. (2021). Tocotrienol-Rich Vitamin E (Tocovid) Improved Nerve Conduction Velocity. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC8618591/

18. Monash University Research. An Underrated Isomer of Vitamin E in Health and Diseases. https://research.monash.edu/files/410025381/409673207.pdf

19. Monash University Research. (2021). Tocotrienol-Rich Vitamin E (Tocovid) Improved Nerve Conduction Velocity. https://research.monash.edu/files/419169134/398697040_oa.pdf

20. Husain, K., et al. (2016). Pharmacokinetics and Safety of Vitamin E δ-Tocotrienol after Single and Multiple Dose Administrations. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC4939900/

21. Nutraceutical Business Review. (2025). American River Nutrition's DeltaGold receives FDA GRAS status. https://nutraceuticalbusinessreview.com/american-river-nutrition-s-deltagold-receives-fda-gras-status-99424

22. Yap, S. P., et al. (2001). Pharmacokinetic characteristics of alpha-, gamma- and delta-tocotrienols under different food status. PubMed. https://pubmed.ncbi.nlm.nih.gov/11206194/

23. Yap, S. P., et al. (2014). Bioavailability of tocotrienols: evidence in human studies. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC3895660/

24. Phang, S. C. W., et al. (2023). Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC10509396/

25. Monash University Research. Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes. https://researchmgt.monash.edu/ws/portalfiles/portal/567569060/501747019_oa.pdf

26. Pervez, M. A., et al. (2021). Effects of delta-tocotrienol supplementation on Glycemic Control. PubMed. https://pubmed.ncbi.nlm.nih.gov/33899292/

27. Pervez, M. A., et al. (2018). Effects of delta-tocotrienol supplementation on liver enzymes in patients with NAFLD. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC6284694/

28. CenterWatch. (2025). A Crossover Clinical Trial Investigating the Effects of Geranylgeraniol Supplementation on Testosterone Levels. https://www.centerwatch.com/clinical-trials/listings/NCT06747624/a-crossover-clinical-trial-investigating-the-effects-of-geranylgeraniol-gg-supplementation-on-testosterone-levels-in-healthy-men-and-women-over-an-18-week-period

29. American River Nutrition. (2022). Annatto Tocotrienol Improves Fatty Liver and Hepatic Steatosis in Patients with NAFLD. https://americanrivernutrition.com/annatto-tocotrienol-improves-fatty-liver-and-hepatic-steatosis-in-patients-with-non-alcoholic-fatty-liver-disease-nafld/

Video: Dr Barrie Tan, Tocotrienols Dosage & When To Take

Dosage Guidelines for Annatto Tocotrienol and Geranylgeraniol (GG)