We're excited to share the latest evidence-based information about these two remarkable natural compounds that can significantly impact your health: annatto tocotrienol (DeltaGold™) and geranylgeraniol (GG-Gold®). These compounds, derived from the annatto plant, represent a powerful combination for preventing and managing various health conditions.

Video: Dr Barrie Tan, Tocotrienols Dosage & When To Take

Dosage Guidelines for Annatto Tocotrienol and Geranylgeraniol (GG)

Based on Latest Clinical Research Evidence

Medical Disclaimer: The dosage recommendations and other health-related information provided are based on published clinical research and are intended for informational and educational purposes only. This content is not meant to substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions regarding a medical condition or treatment.

What is Annatto Tocotrienol?

Annatto tocotrienol, specifically the DeltaGold™ variety, is the most potent form of vitamin E available today. Unlike common alpha-tocopherol found in most vitamin E supplements, annatto tocotrienol contains 90% delta-tocotrienol and 10% gamma-tocotrienol – the most biologically active forms of vitamin E. This unique composition makes it up to 50 times more powerful as an antioxidant compared with traditional vitamin E.

What is Geranylgeraniol (GG)?

Geranylgeraniol (GG) is a vital isoprenoid compound essential for producing CoQ10 and vitamin K2 (MK4), while supporting multiple crucial cellular processes. Adequate GG levels are necessary for optimal energy production, testosterone synthesis, and bone health.

Top 5 Research-Backed Health Benefits & Specific Dosing

1. CARDIOVASCULAR HEALTH

⭐ Strongest Evidence

Clinical Evidence: Multiple randomized controlled trials demonstrate exceptional cardiovascular protection [(https://www.nutraingredients.com/Article/2015/01/08/Clinical-trial-supports-cardiovascular-benefits-of-annatto-tocotrienols/)].

Proven Benefits:

• Reduces total cholesterol by 15% and LDL cholesterol by 18%

• Decreases triglycerides by 14% and C-reactive protein by up to 40%

• Down-regulates inflammatory cytokines (TNF-α, IL-6) by 39-64%.

Dosing Protocol:

• General heart health: 150-300 mg tocotrienol + 75-150 mg GG daily

• Cholesterol management: 250 mg tocotrienol daily (optimal dose)[(https://nutraceuticalbusinessreview.com/clinical-study-confirms-cardiovascular-benefits-of-annatto-tocotrienols--104638)]

• Advanced CVD: Up to 600 mg tocotrienol daily (split doses)

• Duration: Minimum 4 weeks for cholesterol benefits, ongoing for maintenance.

2. BRAIN HEALTH & NEUROPROTECTION

⭐ Strong Evidence

Clinical Evidence: Crosses blood-brain barrier, provides exceptional neuroprotection [(https://pmc.ncbi.nlm.nih.gov/articles/PMC1847628/)] [(https://www.ahajournals.org/doi/10.1161/strokeaha.113.004449)].

Proven Benefits:

• Attenuates white matter lesion progression over 2 years

• Protects from glutamate toxicity and reduces beta-amyloid

• Improves cognitive performance in mild cognitive impairment.

Dosing Protocol:

• General brain health: 200-300 mg tocotrienol + 150 mg GG daily

• Dementia/MCI prevention: 300-400 mg tocotrienol + 150-300 mg GG daily

• White matter lesions: 400 mg tocotrienol daily (200 mg twice daily)[(https://www.ahajournals.org/doi/10.1161/strokeaha.113.004449)]

• Duration: Minimum 12 weeks, 2 years for white matter protection.

3. LIVER HEALTH (NAFLD)

⭐ Strong Clinical Evidence

Clinical Evidence: Multiple 12-48 week randomized controlled trials[(https://americanrivernutrition.com/annatto-tocotrienol-improves-fatty-liver-and-hepatic-steatosis-in-patients-with-non-alcoholic-fatty-liver-disease-nafld/)] [(https://pmc.ncbi.nlm.nih.gov/articles/PMC6284694/)].

Proven Benefits:

• Reduces liver enzymes (ALT/AST) by 18-21%

• Decreases fatty liver index by 15%

• Improves hepatic steatosis and reduces inflammation.

Dosing Protocol:

• General liver support: 300-450 mg tocotrienol daily

• Mild NAFLD: 600 mg tocotrienol daily (300 mg twice daily)[(https://pmc.ncbi.nlm.nih.gov/articles/PMC6284694/)]

• Moderate-Severe NAFLD: 600 mg tocotrienol daily for 12-48 weeks[(https://americanrivernutrition.com/annatto-tocotrienol-improves-fatty-liver-and-hepatic-steatosis-in-patients-with-non-alcoholic-fatty-liver-disease-nafld/)]

• Duration: 12 weeks minimum, up to 48 weeks for severe cases.

4. BONE HEALTH & OSTEOPOROSIS PREVENTION

⭐ Strong Combined Evidence

Clinical Evidence: GG prevents bisphosphonate-related osteonecrosis, stimulates osteoblast activity[(https://pmc.ncbi.nlm.nih.gov/articles/PMC9114760/)]. Beneficial effect of dietary geranylgeraniol on glucose homeostasis and bone microstructure [(https://www.sciencedirect.com/science/article/abs/pii/S0271531721000439)] [(https://pmc.ncbi.nlm.nih.gov/articles/PMC8464510/)].

Proven Benefits:

• Restores bone formation cycles compromised by bisphosphonates

• Improves bone mineral density and cortical thickness

• Reduces bone resorption markers.

Dosing Protocol:

• Prevention: 300 mg tocotrienol + 150-300 mg GG daily

• Osteopenia/Osteoporosis: 300-600 mg tocotrienol + 150-300 mg GG daily

• With bisphosphonates: 300-600 mg tocotrienol + 150-300 mg GG (topical or oral)[(https://pmc.ncbi.nlm.nih.gov/articles/PMC9114760/)]

• Duration: Ongoing, with regular monitoring.

5. CANCER PREVENTION & SUPPORT

⭐ Strong Preclinical & Emerging Clinical Evidence

Clinical Evidence: Multiple studies show anti-cancer properties across various cancer types [(https://pmc.ncbi.nlm.nih.gov/articles/PMC2600692/)] [(https://pmc.ncbi.nlm.nih.gov/articles/PMC8472290/)] [(https://vuir.vu.edu.au/43939/1/463210_early_in_press.pdf)] [(https://www.sciencedirect.com/science/article/pii/S095528631630239X)].

Proven Benefits:

• Induces apoptosis in cancer cells via NF-κB inhibition

• Reduces tumour proliferation and angiogenesis

• Synergistic with chemotherapy (docetaxel).

Dosing Protocol:

• Prevention: 200-400 mg tocotrienol daily

• Active cancer support: 200-1,600 mg tocotrienol daily (2-4 weeks pre-surgery) [(https://pmc.ncbi.nlm.nih.gov/articles/PMC8472290/)] [(https://vuir.vu.edu.au/43939/1/463210_early_in_press.pdf)]

• Duration: Ongoing for prevention, 2-4 weeks pre-surgery for active treatment.

Additional Research-Backed Benefits

Eye Health (Diabetic Retinopathy)

Clinical Evidence: 12-month RCT shows significant retinal protection [(https://pmc.ncbi.nlm.nih.gov/articles/PMC10236897/)][(https://www.casi.org/node/1586)] [(https://research.monash.edu/files/410025381/409673207.pdf)].

• Dosing: 400 mg tocotrienol daily (200 mg twice daily)

• Duration: 12 months minimum

• Benefits: 48% reduction in macular edema, 23% reduction in retinal hemorrhage.

Metabolic Health & Diabetes

Clinical Evidence: Improves glycemic control and insulin sensitivity [(https://americanrivernutrition.com/annatto-tocotrienol-improves-glycemic-control-in-patients-with-type-2-diabetes-mellitus-2/)] [(https://pmc.ncbi.nlm.nih.gov/articles/PMC10509396/)] [(https://www.casi.org/vitamin-e-tocotrienols-cardiometabolic-solution)].

• Tocotrienol: 250-400 mg daily for 24 weeks

• Geranylgeraniol: 150-300 mg daily for glucose homeostasis[(https://www.sciencedirect.com/science/article/abs/pii/S0271531721000439)][(https://pmc.ncbi.nlm.nih.gov/articles/PMC8464510/)].

Hormonal Health (Testosterone Support)

Clinical Evidence: GG increases testosterone in men with low baseline levels [(https://wellnessextract.com/blogs/wellness/breaking-barriers-the-impact-of-geranylgeraniol-on-testosterone-levels)] [(https://americanrivernutrition.com/geranylgeraniol-supplementation-may-benefit-males-with-low-testosterone-clinical-study/)] [(https://pubmed.ncbi.nlm.nih.gov/26757775/)].

• Dosing: 150-300 mg GG daily

• Duration: 12-18 weeks

• Benefits: 7.5% increase in total testosterone, 15% increase in free testosterone.

Muscle Health & Mitochondrial Function

Clinical Evidence: GG reduces muscle atrophy, improves mitochondrial quality [(https://wellnessextract.com/blogs/wellness/the-science-behind-geranylgeraniol-muscle-and-bone-health-explained)] [(https://pmc.ncbi.nlm.nih.gov/articles/PMC9677755/)].

• Dosing: 150-300 mg GG daily

• Duration: Ongoing

• Benefits: Increased muscle cross-sectional area, improved mitochondrial dynamics.

Product Recommendations Based on Health Goals

For Healthy Individuals (Prevention)

Starting Recommendation: Eannatto® DeltaGold™ 150+ – one gel capsule daily with evening meal

• 150mg DeltaGold™ tocotrienol

• 75mg GG-Gold® geranylgeraniol

• Optimal 2:1 ratio for synergistic benefits.

For Mild Existing Conditions

Begin with prevention dose, then increase to one capsule twice daily (breakfast and dinner) if needed:

• Daily Total: 300mg tocotrienol + 150mg geranylgeraniol.

For Advanced Chronic Conditions

Dosage: 450-600mg tocotrienol daily, split across multiple meals
Note: Taking more than 300mg tocotrienol at one time does not increase effectiveness.

Individual Products for Customised Dosing

• Eannatto® DeltaGold™ Tocotrienol Only: 125mg or 300mg gel capsules

• GG-Essential: 150mg pure annatto-derived GG-Gold®.

Critical Timing and Absorption Guidelines

Always Take With Meals

Tocotrienol and GG are fat-soluble nutrients requiring bile secretion for optimal absorption. Taking with food increases absorption by 2-3 fold compared to fasting.

Optimal Timing

• Single daily dose: Take with largest meal (typically dinner)

• Split dosing: Take with breakfast and dinner for even absorption.

Maximum Single Dose

Never exceed 300mg tocotrienol in a single dose. Split higher daily totals between meals.

Pharmacokinetics

• 125-250mg: Peak absorption (Tmax) ≈ 3 hours

• 500mg: Peak absorption (Tmax) ≈ 6 hours

• Half-life: Short (~1.4-2.5 hours), supporting split dosing.

Safety Profile

Clinical Safety Data

• Up to 600mg daily for 12 weeks: No adverse effects

• Up to 900mg daily for 24 months: Safely tolerated

• Up to 1,600mg daily: No serious adverse events

• FDA GRAS recognition for DeltaGold™ tocotrienol

• TGA listing for DeltaGold™ tocotrienol with approved claims (ARTG 373033).

Geranylgeraniol Safety

• 150-300mg daily: Well tolerated

• High safety margins confirmed in animal studies

• FDA GRAS recognition for GG-Gold™ geranylgeraniol.

Important Considerations

• Avoid alpha-tocopherol supplements (interfere with tocotrienol benefits)

• Medication interactions: Generally safe, GG may help reduce statin-related muscle pain

• Pregnancy & breastfeeding: Consult healthcare provider

• Children: No established dosing

• Chronic conditions: Best managed under clinician guidance.

Monitoring Your Progress

Timeline for Benefits

• Weeks 1-4: Early cellular protection

• Months 1-3: Improved energy and well-being

• Months 3-6: Biomarker improvements (cholesterol, CRP, glucose)

• 6+ months: Sustained benefits for long-term health.

Recommended Monitoring

• Lipid profile (cholesterol, triglycerides)

• Inflammatory markers (CRP)

• Blood pressure & glucose levels

• Bone density (if relevant to condition).

Complete Reference List

1. Clinical study confirms cardiovascular benefits of annatto tocotrienols

2. Beneficial effect of dietary geranylgeraniol on glucose homeostasis and bone microstructure

3. The Role of Geranylgeraniol in Managing Bisphosphonate-Related Osteonecrosis of the Jaw

4. Annatto Tocotrienol Improves Fatty Liver and Hepatic Steatosis in Patients with NAFLD

5. Beneficial effect of dietary geranylgeraniol on glucose homeostasis and bone microstructure in obese mice

6. Tocotrienol-rich fraction reduces retinal inflammation and angiogenesis in rats with streptozotocin-induced diabetes

7. Latest on Vitamin E Tocotrienols for Eye Health With Type 2 Diabetes

8. Geranylgeraniol Supplementation Mitigates Soleus Muscle Atrophy via Changes in Mitochondrial Quality in Diabetic Rats

9. The Effect of Geranylgeraniol on Testosterone Levels

10. Geranylgeraniol Supplementation May Benefit Males with Low Testosterone

11. Geranylgeraniol enhances testosterone production via the cAMP/PKA signaling pathway

12. Annatto Tocotrienol Improves Glycemic Control in Patients with Type 2 Diabetes Mellitus

13. Characterization of the potent neuroprotective properties of tocotrienols

14. Clinical trial supports cardiovascular benefits of annatto tocotrienols

15. Effects of delta-tocotrienol supplementation on liver enzymes in patients with NAFLD

16. Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

17. Vitamin E Tocotrienols: The Ultimate Cardiometabolic Solution

18. Clinical Investigation of the Protective Effects of Palm Vitamin E Tocotrienols on Brain White Matter

19. Comparison of delta-tocotrienol and alpha-tocopherol effectiveness in NAFLD

20. γ-Tocotrienol suppresses prostate cancer cell proliferation and invasion

21. Study supports eye health benefits of annatto tocotrienols

22. Tocotrienols as an Anti-Breast Cancer Agent

23. Revisiting the therapeutic potential of tocotrienol

24. An Underrated Isomer of Vitamin E in Health and Diseases - Diabetic Retinopathy

Contact Information: For inquiries about annatto tocotrienol and geranylgeraniol dosages, please contact Natural Health using form below or via email to: aj@naturalhealthconnect.com.au

Always consult with a qualified healthcare provider before starting any new supplement regimen, especially if you have existing health conditions or take medications. This information is for educational purposes and should not replace professional medical advice.