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Annatto Tocotrienol: Breakthrough in Healthier Ageing
Discover the groundbreaking clinical trial on annatto tocotrienol, a unique form of vitamin E, showing its remarkable benefits for healthier ageing and metabolism. Learn how it supports postmenopausal women with low bone density.
FATTY LIVER DISEASEANTI-AGEINGCANCERCARDIOVASCULAR HEALTHLONGEVITYMETABOLIC HEALTHTYPE 2 DIABETESBRAIN HEALTHINFLAMMATIONBONE HEALTHMUSCLE HEALTHCELLULAR HEALTH
AlexanderJ
9/12/20252 min read
What the Study Found
Researchers discovered that annatto tocotrienol:
✅ Strengthens Bones and Collagen – reduced markers of bone breakdown, confirming its role in supporting bone density https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.766711/full
✅ Fights Oxidative Stress – lowered harmful by-products that damage cells, conserving key amino acids like methionine and cysteine for repair and protection.
✅ Supports Gut and Hormone Health – shifted tryptophan and tyrosine metabolism (linked to the gut microbiome) and influenced hormone pathways including progesterone and DHEA
✅ Improves Lipid and Cell Membrane Function – raised levels of lysophospholipids and protective fatty acids, important for reducing inflammation and maintaining healthy cell membranes.
In other words, annatto tocotrienol doesn’t just “add in” nutrients, it resets the way the body uses and protects them, helping maintain balance at a biochemical level.
Why This Matters
For postmenopausal women, this means better bone support, less oxidative stress, and healthier metabolism. But these benefits extend to all adults. Because tocotrienols act at the fundamental level of cellular health, their effects apply broadly, supporting heart health, brain function, immune balance, and healthy ageing.
Dr. Barrie Tan, one of the world’s leading experts on vitamin E, called this study:
“The first time ever that annatto tocotrienol was shown to globally affect the nutritional biochemistry in the human body… This is the type of study structure-function claims are built upon, a Holy Grail in the dietary supplement industry that’s nearly impossible to reach.”
The Bottom Line
This trial confirms what decades of research have suggested: annatto tocotrienol is a powerful, natural nutrient for whole-body wellness. It helps the body defend against stress, protect bones, balance hormones, and support healthy metabolism at every stage of life.
If you’re looking for a safe, science-backed way to enhance vitality and resilience, annatto tocotrienol deserves a place at the top of your list.
References
Shen C-L, Mo H, Dunn DM, Watkins BA. Tocotrienol Supplementation Led to Higher Serum Levels of Lysophospholipids but Lower Acylcarnitines in Postmenopausal Women: A Randomized Double-Blinded Placebo-Controlled Clinical Trial. Frontiers in Nutrition. 2021;8:766711. doi:10.3389/fnut.2021.766711.
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.766711/full
Qureshi AA, et al. Impact of δ-Tocotrienol on Inflammatory Biomarkers and Oxidative Stress in Hypercholesterolemic Subjects. Journal of Clinical & Experimental Cardiology. 2015;6(3):1000370. Available from: https://www.longdom.org/open-access/impact-of-948tocotrienol-on-inflammatory-biomarkers-and-oxidative-stress-in-hypercholesterolemic-subjects-50077.html
Nutraceutical Business Review. Clinical study confirms cardiovascular benefits of annatto tocotrienols. Nutraceutical Business Review. 2015. Available from: https://www.nutraceuticalbusinessreview.com/news/article_page/Clinical_study_confirms_cardiovascular_benefits_of_annatto_tocotrienols/104638